Amines
REACH
N-Methyl-D-glucamine
CAS Number
6284-40-8
EC Number
228-506-9
What is N-Methyl-D-glucamine?
N-Methyl-D-glucamine (CAS 6284-40-8), commercially recognized as Meglumine, is a sugar-derived amine used primarily as a salt-forming agent and solubilizer in pharmaceutical manufacturing.
Where is N-Methyl-D-glucamine used?
- Pharmaceuticals: salt-forming agent and solubilizer converting poorly water-soluble APIs into injectable or oral meglumine salts
- Contrast media: counterion for diatrizoate meglumine and iomepamide in diagnostic imaging injectables
- Antiparasitic and antifungal APIs: solubilization
- Leishmaniasis treatment: meglumine antimoniate
- Topical and transdermal delivery: pH adjuster and humectant carrier in semi-solid formulations
- Personal care: stabilizer and solubilizer of active ingredients in moisturizing serums and treatment creams
- It improves bioavailability and formulation performance across drug delivery systems.
Good to know: Pharmaceutical-grade material meets USP, BP and Ph. Eur. specifications for injectable and oral drug product manufacturing; technical-grade material is offered for non-pharmaceutical industrial applications.
Other Names (Synonyms)
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol|Meglumine
What are the physical properties of N-Methyl-D-glucamine?
Melting Point 128.5 °C
Boiling Point 331.88°C (rough estimate)
Density 1.2669 (rough estimate)
Appearance white to almost white crystalline powder
Color White to almost white
Form Crystalline Powder
Water Solubility 100 g/100 mL (25 ºC)
Refractive Index -16.5 ° (C=2, H2O)
pH 11 (10g/l, H2O, 20℃)
Log P -3.370 (est)
Which trade and regulatory codes apply to N-Methyl-D-glucamine?
HS Code 29221980
Storage Class 11 - Combustible Solids
WGK (Germany) 3