S-adenosylmethionine

S-adenosylmethionine (CAS 29908-03-0), commonly known as SAMe or AdoMet, is a naturally occurring methyl donor central to enzymatic transmethylation reactions across pharmaceutical, nutraceutical, and biochemical research applications.

It functions as a cosubstrate in over 100 enzymatic reactions, making it a high-value active ingredient in both finished dosage forms and research workflows. In pharmaceutical and nutraceutical manufacturing, SAMe is formulated into oral supplements.

These prescription products target liver function support and mood-related indications. Biochemistry and drug discovery labs use AdoMet as a reference standard and reaction substrate in methyltransferase assays, epigenetics research, and enzyme kinetics studies.

In cosmetic formulations, it is incorporated into anti-aging and skin-conditioning products where methyl donor activity supports cellular repair pathways relevant to formulators. Contract manufacturers producing enteric-coated tablets rely on stabilized SAMe salts.

These salts protect the compound through processing and shelf life. S-adenosylmethionine is supplied primarily as a crystalline powder in stabilized salt forms, most commonly the tosylate disulfate and butanedisulfonate salts.

Pharmaceutical-grade material is available to USP and BP specifications, while research-grade material is offered at defined purity levels for laboratory use. Packaging ranges from small quantities for R&D to bulk quantities for commercial manufacturing.