Sodium methanethiolate

Sodium methanethiolate (CAS 5188-07-8), also known as sodium thiomethylate, is a reactive organosulfur nucleophile used across pharmaceutical synthesis, agrochemical manufacturing, and polymer chemistry. SMM functions primarily as a methylthiolation reagent, introducing the methylthio group into target molecules under controlled reaction conditions. In pharmaceutical manufacturing, it is a key intermediate.

It is used in the synthesis of active pharmaceutical ingredients where selective sulfur alkylation is required, including certain antibiotics and cardiovascular compounds. Agrochemical producers use it for functionality. It introduces methylthio functionality into herbicide and pesticide molecules during multi-step synthesis. In polymer and plastics processing, it acts as a catalyst or chain-transfer agent to control weight.

It is used to modify end-group chemistry in various materials. The oil and gas sector applies sodium thiomethylate in scavenger formulations and as a pH-regulating additive in refinery process streams. Sodium methanethiolate is supplied as a liquid solution, typically in aqueous or methanolic form, with concentration ranges commonly between 20% and 40% by weight for industrial use.

Technical and synthesis grades are the standard commercial offerings, with pharmaceutical-grade material available from select manufacturers to meet API intermediate specifications for high purity. Packaging ranges from drums to IBC totes depending on volume requirements. This ensures safe handling and transport of the chemical across global supply chains for diverse manufacturing needs.