Vitamin B3 Nicotinamide

Nicotinamide (CAS 98-92-0), also known as niacinamide and designated E375 in food applications, is the amide form of vitamin B3.

Where is Vitamin B3 Nicotinamide used?

• Pharmaceuticals: active ingredient in vitamin B3 supplements, multivitamin tablets and therapeutic preparations targeting pellagra and metabolic disorders
• Food and beverage: approved nutrient fortifier in cereals, infant formula and functional drinks, restoring or enhancing B-vitamin content
• Cosmetics: skin-conditioning agent in serums, moisturizers and anti-aging creams that supports skin barrier function and helps reduce hyperpigmentation
• Feed premixes and veterinary nutritional products: cost-effective B-vitamin source
• It also acts as a formulation stabilizer depending on the end market.
• Used as an additive in cleaning products.
• Used as a component in paint and chemical formulations.

Good to know: Pharmaceutical grades are subject to stricter purity and heavy metal limits. Recognized quality standards include USP, BP, Ph. Eur. and FCC.

Formulation notes

• Combination with vitamin A palmitate enhances skin lightening properties.

Typical specification

• Taste-masked grades are available on the market to mask bitter taste.
• Non-GMO; produced by chemical synthesis to create nature-identical vitamins.
• USP grade contains not less than 98.5% and not more than 101.5% of niacinamide, calculated on the dried basis.

Regulatory status

• The HS code is 29362920 or 29362900.
• For the pharmaceutical markets of Europe, the US and Japan, certifications include CEP, USDMF and Japan DMF respectively.

Storage, packaging and handling

• Stable in dry form.
• Should be kept sealed in a cool, dry place.

Frequently asked questions about Vitamin B3 Nicotinamide

What regulatory methods exist for determining niacinamide in feed additives?

Commission Implementing Regulation (EU) 2024/1194 recommends methods for its determination as a feed additive in the EU.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.