Vitamin B3 Nicotinic Acid

Nicotinic acid (CAS 59-67-6), also known commercially as E375 and Niacin, is a water-soluble B-vitamin (B3).

Where is Vitamin B3 Nicotinic Acid used?

• Food and beverage: nutrient fortifier and acidulant for flour and cereal fortification, restoring B-vitamin content lost during processing
• Pharmaceutical: active ingredient in vitamin B3 supplements and precursor in the synthesis of nicotinamide
• Personal care: supports skin-conditioning actives for uneven tone and barrier function
• Specialty chemicals: ligand or precursor in catalyst systems for organic synthesis
• It functions as a catalyst precursor depending on the application sector.
• Used as a prescription medicine.
• Used to treat high cholesterol.
• Reduces dark spots and increases collagen production.
• Nixtamalization of corn with calcium hydroxide makes its niacin absorbable.

Formulation notes

• May increase the vasodilator effect and postural hypotension associated with antihypertensive drugs.
• Use with HMG-CoA reductase inhibitors may cause rhabdomyolysis and myopathies.
• Niacin in some cereal grains is bound to fiber, which decreases its absorption.
• Nicotinamide is generally well tolerated, unlike nicotinic acid, which carries the listed adverse effects and contraindications.

Typical specification

• Offered in API USP, BP, Ph Eur, and FCC food grades.
• All vitamin B3 products are non-GMO and produced by chemical synthesis to create nature-identical vitamins.
• Buyers should clarify whether they need the hydrochloride (HCl), anhydricum, base or micronisatum form, or a specific purity level.
• Has an HS code of 29362920.

Regulatory status

• Health claims for vitamin B3 are authorized in the EU with specific conditions of use.
• Many countries mandate the addition of nicotinic acid to wheat flour or other food grains.
• Listed in the European Pharmacopoeia (Ph Eur).

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.