Flavors & Fragrances
REACH
Benzyl nicotinate
CAS Number
94-44-0
EC Number
202-332-3
What is Benzyl nicotinate?
Benzyl nicotinate (CAS 94-44-0) is an ester of nicotinic acid used primarily as a topical vasodilator active in pharmaceutical and cosmetic formulations. Also marketed as nicotinic acid benzyl ester.
Where is Benzyl nicotinate used?
- Pharmaceutical topicals: creams, gels and patches for circulation in muscle and joint relief
- Cosmetics: warming massage oils, body slimming creams and anti-cellulite treatments
- Perfumery: fragrance modifier and fixative
- It serves as a building block in the synthesis of more complex nicotinic acid derivatives.
Good to know: Its localized warming (flushing) effect is the intended mechanism in rubefacient and skin-conditioning products.
Commercial specifications
- High-purity material typically exceeds 98% as confirmed by HPLC
- Packaging from kilogram-scale laboratory quantities to bulk commercial orders
Other Names (Synonyms)
phenylmethyl 3-pyridinecarboxylate|Nicotinic acid benzyl ester|benzyl pyridine-3-carboxylate|3-pyridinecarboxylic acid phenylmethyl ester|Rubriment|Pycaril|Pykaryl|S497LCF9C9
What are the physical properties of Benzyl nicotinate?
Melting Point 24 °C
Boiling Point 165 °C @ Press: 2 Torr
Density 1,1165 g/cm 3
Flash Point 170°C
Color Colourless to Light Beige
Form neat
Refractive Index n 20/D 1.570
Log P 2.400
How is Benzyl nicotinate classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
Precautionary Statements
P264 Wash … thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P264+P265 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Benzyl nicotinate?
HS Code 2933399990
Storage Class 11 - Combustible Solids
WGK (Germany) 2