Hexyl nicotinate

Hexyl nicotinate (CAS 23597-82-2), also known as nicotinic acid hexyl ester, is an ester of nicotinic acid used as a penetration enhancer and carrier in topical formulations. It promotes localized vasodilation at the skin surface, making it a functional active in cosmetic and pharmaceutical products targeting circulation and warmth response for various applications.

In topical pharmaceutical formulations, it is incorporated into creams and gels designed to produce a warming or flushing sensation, commonly used in muscle rub and sports recovery products. Cosmetic formulators use it in anti-cellulite creams and body contouring products where visible skin redness and improved microcirculation are desired endpoints for the end user.

It also functions as a carrier and penetration enhancer, improving transdermal delivery of co-formulated actives through the skin barrier to ensure maximum efficacy of the final product. In pharmaceutical intermediate applications, it serves as a building block for synthesizing nicotinic acid derivatives and related heterocyclic compounds used in advanced chemical synthesis.

The product is supplied as a clear to pale yellow liquid. It is available in technical and cosmetic-grade specifications, with purity levels typically at 98% or higher confirmed by GC analysis. Packaging options generally range from small laboratory quantities up to bulk drum supply for industrial formulators, ensuring flexible logistics for different manufacturing requirements.