Coenzyme a

Coenzyme A (CAS 85-61-0), commonly abbreviated as CoA or referenced as CoASH and HSCoA in biochemical sourcing contexts, is a critical cofactor involved in acyl group transfer reactions across metabolic pathways. In commercial and research settings, it functions as a biochemical reagent enabling enzymatic synthesis, assay development, and the production of acylated intermediates for various industrial applications.

In pharmaceutical manufacturing, CoA supports the synthesis of acetyl-CoA-dependent intermediates used in active pharmaceutical ingredient development and metabolic pathway research for drug discovery. Biotechnology and life sciences buyers source it primarily for in vitro enzyme activity assays, coenzyme-dependent reaction screening, and metabolic flux studies in laboratory environments.

Cosmetic formulators incorporate CoA-based systems into advanced skin care actives targeting cellular energy metabolism and moisture retention at the formulation level for high-end products. It also serves as a reference standard and substrate in diagnostic kit manufacturing, where consistent purity and activity are procurement-critical requirements for quality control.

Coenzyme A is supplied as a lyophilized powder or as a sodium salt form, with the free acid and lithium salt variants also available depending on specific application requirements. Standard grades include research-grade and high-purity biochemical-grade material, with specifications typically defined by enzymatic activity rather than conventional chemical purity alone.