Thymidine monophosphate

Thymidine monophosphate (CAS 365-07-1), also known as dTMP or 5'-thymidylic acid, is a nucleotide monophosphate used as a biochemical building block in pharmaceutical synthesis and life science research.

Where is Thymidine monophosphate used?

• Pharmaceutical manufacturing: intermediate
• Synthesis of antiviral and anticancer nucleotide analogues, where structural purity affects downstream API quality
• Cell culture media formulations that supplement nucleotide pools and support proliferation of nucleotide-auxotrophic cell lines
• Enzymatic assay systems and polymerase chain reaction reagents, where defined nucleotide concentrations are critical to assay reproducibility
• Research-scale synthesis of oligonucleotides and labeled DNA probes for molecular diagnostics development

Commercial specifications

• Purity specifications commonly at ≥98% or ≥99% by HPLC
• Packaging ranges from milligram quantities to kilogram lots