Diphenhydramine hydrochloride
What is Diphenhydramine hydrochloride?
Diphenhydramine hydrochloride (CAS 147-24-0), commonly referenced as diphenhydramine HCl, is an antihistamine active pharmaceutical ingredient used in prescription and OTC drug manufacturing.
Where is Diphenhydramine hydrochloride used?
- OTC pharmaceuticals: active ingredient in oral tablets, capsules and liquid formulations for allergy and nighttime sleep products
- Topical drug products: antipruritic agent in creams, gels and sprays for skin irritation and insect bite reactions
- Hospital and clinical injectables: API requiring tightly controlled purity specifications
- In personal care it appears in select cosmetic formulations where antipruritic or soothing claims are supported by regulatory frameworks.
Good to know: Technical-grade material is also available for non-pharmaceutical industrial applications where compendial certification is not required.
Commercial specifications
- USP, BP and Ph. Eur. grades
Other Names (Synonyms)
diphenhydramine HCl|beta-dimethylaminoethyl benzhydryl ether hydrochloride|alpha-hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride|2-benzhydryloxyethyl(dimethyl)amine;hydrochloride|2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride|2-(diphenylmethyl)oxy-N,N-dimethyl-ethanamine;hydrochloride|2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride|2-(benzhydryloxy)-N,N-dimethylethylamine hydrochloride|HCl, DPH HCl