Levocetirizine dihydrochloride

CAS Number
130018-87-0
EC Number
641-093-3

What is Levocetirizine dihydrochloride?

Levocetirizine dihydrochloride (CAS 130018-87-0) is the active pharmaceutical ingredient (API) used in second-generation antihistamine formulations. Also referenced under the brand name Xyzal.

Where is Levocetirizine dihydrochloride used?

  • Pharmaceutical manufacturing: active enantiomer of cetirizine for finished dosage forms targeting allergic conditions and respiratory relief
  • Oral solid dosage: active ingredient in prescription and OTC antihistamine tablets and film-coated tablets
  • Oral solutions and syrups: liquid-compatible API grades for pediatric product lines requiring precise dosing and stability
  • Personal care and cosmetics: topical and dermatological formulations pursuing anti-allergic skin relief claims under applicable regulatory frameworks

Commercial specifications

  • Packaging in controlled quantities suitable for pharmaceutical manufacturing environments
  • Documentation including CoA, DMF references, and impurity profiles upon request

Other Names (Synonyms)

Xyzal|SOD6A38AGA|Xyzal Allergy 24hr|cetirizine (R)-form dihydrochloride|CETIRIZINE HYDROCHLORIDE (R)-|Xusal

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What are the physical properties of Levocetirizine dihydrochloride?

Melting Point 215-220°C
Color White to Almost white
Form powder
Water Solubility H2O: ≥23mg/mL

How is Levocetirizine dihydrochloride classified and handled safely? Learn More

Warning
GHS07· Irritant GHS09· Environmental Hazard

Hazard Statements

H302 Harmful if swallowed
H400 Very toxic to aquatic life

Precautionary Statements

P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P330 Rinse mouth.

Which trade and regulatory codes apply to Levocetirizine dihydrochloride?

HS Code 29335990
UN Number 3077
ADR Class 9
Packing Group III
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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