Lidocaine
CAS Number
137-58-6
EC Number
200-179-1
What is Lidocaine?
Lidocaine (CAS 137-58-6), also known by the trade name Xylocaine®, is a synthetic amino amide compound used as a local anesthetic and topical analgesic.
Where is Lidocaine used?
- Pharmaceutical manufacturing: injectable solutions for regional and local anesthesia in surgical, dental, and emergency care
- Topical dosage forms: creams, gels, patches, and sprays for surface-level pain and itch relief
- Personal care and cosmetics: numbing creams ahead of aesthetic procedures such as tattooing, laser treatments, and minor dermal interventions
- Combination formulations target premature ejaculation, hemorrhoid relief, and wound care.
Good to know: It functions by blocking nerve signal transmission. The hydrochloride salt is the preferred grade for aqueous injectable and topical formulations due to its water solubility.
Commercial specifications
- Free base and hydrochloride salt forms
- API-grade material supported by full regulatory documentation
Other Names (Synonyms)
α-diethylamino-2,6-dimethylacetanilide|Xylocaine®|alpha-diethylamino-2,6-dimethylacetanilide|2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|2-(Diethylamino)-2',6'-acetoxylidide|Duncaine|Lidoderm|Esracaine
What are the physical properties of Lidocaine?
Melting Point 68.5 °C
Boiling Point 159-160 °C @ Press: 2 Torr
Density 1.026 g/cm³
Flash Point 9°C
Appearance solid
Color White to slightly yellow
Form powder
Water Solubility practically insoluble
Refractive Index 1.5110 (estimate)
Log P 2.440
How is Lidocaine classified and handled safely? Learn More
Warning
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H362 May cause harm to breast-fed children
H370 Causes damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
Which trade and regulatory codes apply to Lidocaine?
HS Code 29242990
Storage Class 11 - Combustible Solids
WGK (Germany) 3