Losartan potassium

Losartan potassium (CAS 124750-99-8) is an angiotensin II receptor antagonist active pharmaceutical ingredient used in the manufacture of antihypertensive drug products. Known under the reference brand Cozaar, it is a finished API supplied to generic drug manufacturers. Generic pharmaceutical manufacturers use this material as the primary API in solid oral dosage forms, including tablets and film-coated tablets targeting hypertension and diabetic nephropathy indications. It is essential for cardiovascular therapies.

Contract development organizations source it for bioequivalence study batches and formulation development against the reference listed drug. It is also procured by compounding pharmacies requiring a documented API for patient-specific preparations. Combination product developers incorporate it alongside diuretics such as hydrochlorothiazide in fixed-dose formulation programs. This versatility makes it a staple in modern pharmaceutical manufacturing and drug development cycles.

The material is supplied as a white to off-white crystalline powder. It is available in USP and EP (Ph.Eur.) grades, with ICH-compliant documentation packages including full DMF or ASMF references. Regulated market buyers typically require these high-quality standards for their supply chains. Quantities range from research-scale to multi-kilogram commercial batches to meet various production needs.

GMP-certified manufacture is expected for finished dosage form supply chains to ensure safety and efficacy. This ensures that the final pharmaceutical products meet all necessary regulatory requirements for global distribution.