Losartan potassium

Losartan potassium (CAS 124750-99-8) is an angiotensin II receptor antagonist active pharmaceutical ingredient used in the manufacture of antihypertensive drug products. Also known under the reference brand Cozaar.

Where is Losartan potassium used?

• Generic pharmaceutical manufacturing: primary API in solid oral dosage forms, including tablets and film-coated tablets for hypertension and diabetic nephropathy
• Contract development: bioequivalence study batches and formulation development against the reference listed drug
• Compounding pharmacies: documented API for patient-specific preparations
• Combination products: fixed-dose programs with diuretics such as hydrochlorothiazide
• It is essential for cardiovascular therapies.

Good to know: Regulated market buyers typically require USP and EP (Ph. Eur.) grades with ICH-compliant documentation packages including full DMF or ASMF references; GMP-certified manufacture is expected for finished dosage form supply chains.

Commercial specifications

• USP and EP (Ph. Eur.) grades
• ICH-compliant documentation packages including full DMF or ASMF references
• Quantities from research-scale to multi-kilogram commercial batches