Disopyramide

Disopyramide (CAS 3737-09-5) is an active pharmaceutical ingredient used in the treatment of cardiac arrhythmias. It functions as a Class Ia antiarrhythmic agent, suppressing abnormal electrical activity in the heart muscle. This compound helps to restore and maintain normal sinus rhythm in patients. It is the primary API in finished oral dosage forms, including capsules and extended-release tablets, indicated for ventricular and supraventricular arrhythmias.

Pharmaceutical manufacturers source this material as a key input for formulating branded and generic antiarrhythmic drug products. It is also used in hypertrophic obstructive cardiomyopathy management to reduce outflow tract obstruction. The clinical utility of this substance expands its relevance beyond standard arrhythmia indications. Research and reference standard laboratories procure small quantities for analytical method development and pharmacokinetic studies.

The material is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications, including USP and BP/Ph.Eur. grades, to meet the quality requirements of regulated drug manufacturing. The phosphate salt form, Disopyramide Phosphate, is the more commonly used variant in finished dosage formulations. This salt is also available under corresponding pharmacopoeial standards such as EP for global distribution.