Pioglitazone
CAS Number
111025-46-8
EC Number
601-029-7
Industries: Pharma & Healthcare
What is Pioglitazone?
Pioglitazone (CAS 111025-46-8) is an oral antidiabetic active pharmaceutical ingredient of the thiazolidinedione class.
Where is Pioglitazone used?
- Type 2 diabetes: insulin sensitizer targeting peripheral tissue resistance
- Solid dosage form development: finished API for pharmaceutical manufacturers
- Tablet formulations: reduces insulin resistance in muscle and adipose tissue
- Monotherapy and fixed-dose combination tablets alongside metformin or glimepiride
- Synthesis research and formulation development pipelines for metabolic disease indications
- CDMOs source it for bioequivalence study batches and commercial-scale tablet production.
Good to know: The hydrochloride salt form is the predominant commercial grade used in finished dosage manufacturing. It works without stimulating pancreatic insulin secretion.
Commercial specifications
- Pharmaceutical-grade specifications, including USP and Ph. Eur. compliant material
- Bulk API in kilogram to multi-kilogram quantities
- CoA, DMF references, and ICH-compliant impurity profiling
Other Names (Synonyms)
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione|5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)thiazolidine-2,4-dione|(+-)-5-({4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl}methyl)-2,4-thiazolidinedione|Glustin|Zactos|5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione|2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-
What are the physical properties of Pioglitazone?
Melting Point 183-184 °C
Boiling Point 575.4±45.0 °C(Predicted)
Density 1.260±0.06 g/cm3(Predicted)
Color White to Off-White
Form White to off-white solid.
How is Pioglitazone classified and handled safely? Learn More
Warning
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.