Aminoguanidine hydrochloride

Aminoguanidine hydrochloride (CAS 1937-19-5), also known as Pimagedine hydrochloride, is a reactive guanidine derivative used primarily as a pharmaceutical intermediate and biochemical research reagent. It functions as a carbonyl-trapping agent and selective inhibitor in synthetic and biological systems, making it a critical building block in drug development workflows for global manufacturers.

In pharmaceutical synthesis, it serves as a key intermediate in the preparation of heterocyclic compounds, including triazines, aminotriazoles, and guanidine-based active pharmaceutical ingredients. Biotechnology researchers use it to study advanced glycation end-product formation, where its carbonyl-scavenging activity is central to mechanistic assays and compound screening programs.

It also functions as a catalyst or reactive intermediate in the synthesis of specialty agrochemical and fine chemical targets requiring guanidine scaffolds for specific industrial applications. Contract manufacturers and API producers source it as a starting material for multi-step synthesis routes targeting cardiovascular and metabolic disease candidates in clinical development.

Aminoguanidine hydrochloride is supplied as a white to off-white crystalline powder. It is available in research-grade and technical-grade specifications with high-purity grades commonly supplied. Packaging ranges from small laboratory quantities to multi-kilogram industrial lots depending on application requirements, ensuring reliable supply for both R&D and large-scale production.