2-bromothiophene

2-Bromothiophene (CAS 1003-09-4), also known as 2-thienyl bromide, is a halogenated heterocyclic building block used across pharmaceutical synthesis and specialty chemical manufacturing. It serves as a reactive intermediate for introducing the thiophene scaffold into complex organic molecules through cross-coupling and metal-catalyzed reactions in various industrial settings.

In pharmaceutical development, this compound is a key precursor for active pharmaceutical ingredients where the thiophene ring is a core structural element, including antifungal and antihistamine compounds. Flavor and fragrance chemists use it to access thienyl-containing aroma compounds through further functionalization. It participates in Suzuki, Kumada, and Negishi coupling reactions for advanced intermediates.

Specialty chemical producers also use it as a starting material for liquid crystal components and conducting polymer monomers, supporting innovation in agrochemical and materials science applications. The product is supplied as a liquid in standard commercial quantities ranging from laboratory-scale packaging to bulk drums. Technical and high-purity grades are available for diverse industrial needs.

Purity specifications are typically at 97–99%+ to meet the demands of pharmaceutical and fine chemical synthesis. Buyers should confirm grade documentation and certificate of analysis requirements. For those sourcing for GMP-regulated processes, ensure the material meets necessary quality standards. Proper handling and storage protocols must be followed to maintain the integrity of the chemical.