2-bromothiophene

CAS Number
1003-09-4
EC Number
213-699-4

What is 2-bromothiophene?

2-Bromothiophene (CAS 1003-09-4), also known as 2-thienyl bromide, is a halogenated heterocyclic building block.

Where is 2-bromothiophene used?

  • Pharmaceutical development: precursor for APIs with a thiophene core, including antifungal and antihistamine compounds
  • Flavor and fragrance: access to thienyl-containing aroma compounds
  • Suzuki, Kumada and Negishi coupling reactions for advanced intermediates
  • Specialty chemicals: starting material for liquid crystal components and conducting polymer monomers
  • It serves as a reactive intermediate for introducing the thiophene scaffold into complex organic molecules.

Good to know: Buyers should confirm grade documentation and certificate of analysis requirements; for GMP-regulated processes, ensure the material meets necessary quality standards. Proper handling and storage protocols must be followed.

Commercial specifications

  • Purity typically 97–99%+
  • Packaging from laboratory scale to bulk drums

Other Names (Synonyms)

2-thienyl bromide|Thiophene, 2-bromo-|GFF929NUW7|Monobromothiophene.

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What are the physical properties of 2-bromothiophene?

Melting Point <25 °C
Boiling Point 53-56 °C @ Press: 18 Torr
Density 1.6284 g/cm³ @ Temp: 20 °C
Flash Point 140 °F
Appearance colorless to light yellow liqui
Color Clear colorless to slightly brownish
Form Liquid
Water Solubility IMMISCIBLE
Refractive Index n 20/D 1.586(lit.)

How is 2-bromothiophene classified and handled safely? Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant

Hazard Statements

H226 H226
H300 H300
H301 H301
H310 H310

Precautionary Statements

P210 P210
P233 P233
P240 P240
P241 P241

Which trade and regulatory codes apply to 2-bromothiophene?

HS Code 29349990
UN Number 2929
ADR Class 6.1
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 3
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