4-nitrobenzoic acid

CAS Number
62-23-7
EC Number
200-526-2
Chemical Formula
C7H5NO4
Molecular Weight
167.12 g/mol

Description

4-Nitrobenzoic acid (CAS 62-23-7), also known as p-Nitrodracylic acid, is an aromatic nitro compound used primarily as a chemical intermediate in pharmaceutical synthesis and dye manufacturing. It functions as a building block for active pharmaceutical ingredients, azo pigments, and specialty organic compounds requiring a para-substituted benzoic acid backbone for specific chemical reactions.

In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of APIs including local anesthetics, antimicrobials, and cardiovascular compounds during the production process. Azo dye and pigment producers use it to introduce nitro functionality into colorant structures, influencing hue and lightfastness in various textile and ink applications across the industry.

In organic synthesis, it acts as a pH buffer and mild preservative in formulation systems where controlled acidity and microbial inhibition are both required for product stability. Personal care formulators have explored it in preservation systems targeting specific microbial strains at low concentrations. The material is supplied as a pale yellow to off-white crystalline powder.

Technical and pharmaceutical-grade material is available, with purity specifications typically ranging from 98% to 99%+ depending on the intended application and the required USP or BP standards. Packaging options generally span from kilogram-scale laboratory quantities to bulk industrial volumes. This ensures flexibility for both research development and large-scale commercial manufacturing needs.

Other Names (Synonyms)

p-Nitrodracylic acid|p-Nitrobenzoic acid|p-Nitrobenzenecarboxylic acid|Nitrodracylic acid|4-Nitrodracylic acid|1-Carboxy-4-nitrobenzene|Benzoic acid, 4-nitro-|Benzoic acid, p-nitro-

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 242 °C
Boiling Point 150 °C @ Press: 0.02 Torr
Density 1.610 g/cm³ @ Temp: 20 °C
Flash Point 237 °C
Appearance light yellow crystalline powder
Color Light yellow
Form Crystalline Powder
Water Solubility <0.1 g/100 mL at 26 ºC
Refractive Index 1.6280 (estimate)
pH 3.1 (0.42g/l, H2O, 20℃)(saturated solution)
Log P 1.890

Safety & Handling (Learn More)

Warning
GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H319 Causes serious eye irritation
H320 Causes eye irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
H360 May damage fertility or the unborn child
H371 May cause damage to organs

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P317 Get emergency medical help.
P318 IF exposed or concerned, get medical advice.
P319 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P316 Get emergency medical help immediately.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29163900
Storage Class 11 - Combustible Solids
WGK (Germany) 1

Documentation

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