Trimethyl orthoformate

Trimethyl orthoformate (CAS 149-73-5), abbreviated TMOF and also known as methyl orthoformate, is a reactive orthoacid ester used as a protecting group reagent and synthetic building block.

Where is Trimethyl orthoformate used?

• Pharmaceutical synthesis: methoxymethylating agent and carbonyl-protecting reagent for API intermediates
• Agrochemical and fine chemical production: formylation reagent introducing formate functionality under mild conditions
• Flavor and fragrance manufacturing: precursor to orthoester-based aroma compounds and stabilizing carrier solvent for sensitive ingredients
• Biotechnology: low-water solvent medium for enzymatic reactions where aqueous conditions compromise yield or selectivity
• It enables controlled reactions in sensitive synthesis environments where conventional reagents cause unwanted side reactions.

Commercial specifications

• Purity typically 98% or higher for pharmaceutical and fine chemical applications
• High-purity reagent grade available for API synthesis and analytical workflows
• Colorless liquid in packaging from small laboratory quantities to bulk drums