Methyl formate

Methyl formate (CAS 107-31-3), also known as R-611, is a fast-evaporating ester solvent used across pharmaceutical synthesis, fumigation, and flavoring applications. Its high solvency power and reactivity as a formylating agent make it a practical choice for both process chemistry and specialty formulations.

In pharmaceutical manufacturing, methyl formate functions as a reaction solvent and intermediate in the synthesis of formic acid, formamide derivatives, and active pharmaceutical ingredients. As a fumigant and grain preservative, it offers broad-spectrum biocidal activity.

It is effective against insects and molds in stored commodities, with a low residue profile that supports food safety compliance. Flavor chemists use it as a fruity top-note ingredient in food and beverage formulations, where its low use levels deliver high olfactory impact.

In industrial foam production, it serves as a blowing agent alternative under the R-611 designation, replacing more regulated halocarbons in polyurethane systems. This versatility makes it a staple in modern chemical manufacturing and agricultural preservation.

Methyl formate is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities. Technical grade is the standard for industrial and fumigation use, while higher-purity grades are available to meet pharmaceutical and food-grade processing requirements.

These high-purity options often align with international quality standards such as FCC, USP, Ph.Eur., BP, EP, or ACS depending on the specific application. Buyers should confirm purity specifications and packaging options directly with suppliers.

Grade designations vary by regional market, so technical data sheets should be reviewed for compliance. Proper handling and storage are essential due to the high volatility and flammability of this ester solvent in industrial environments.