Solvents
REACH
Dimethylformamide
CAS Number
68-12-2
EC Number
200-679-5
Abbreviation
DMF
What is Dimethylformamide?
Dimethylformamide (CAS 68-12-2), commercially known as DMF, is a high-boiling polar aprotic solvent.
Where is Dimethylformamide used?
- Pharmaceutical manufacturing: reaction solvent and purification medium for active pharmaceutical ingredients
- Acrylic fiber and synthetic leather: dissolves polyacrylonitrile and polyurethane resins into spinnable or coatable forms
- Electronics: strips and cleans photoresist layers during PCB and semiconductor fabrication
- Agrochemical synthesis: solvent and catalyst precursor
- It dissolves a broad range of organic and inorganic compounds where water-miscible, low-volatility performance is required.
Good to know: Specifications are aligned to USP and Ph. Eur. pharmacopeial standards where API manufacturing requires it.
Commercial specifications
- Clear liquid in drums, IBCs, and bulk tanker quantities
- Technical grade and high-purity pharmaceutical grade
- Low-water and anhydrous variants for moisture-sensitive synthesis
Other Names (Synonyms)
N,N-Dimethylformamide|N-Formyldimethylamine|Dimethylamid kyseliny mravenci|DMF|Formamide, N,N-dimethyl-|DMFA|Dimethylformamide DMF
What are the physical properties of Dimethylformamide?
Melting Point -61 °C
Boiling Point 153 °C @ Press: 760 Torr
Density 0.9445 g/cm³ @ Temp: 25 °C
Flash Point 136 °F
Appearance Clear colorless liquid
Color APHA: ≤15
Odor Faint, ammonia-like odor detectable at 100 ppm
Form Powder
Water Solubility soluble
Vapor Pressure 2.7 mm Hg ( 20 °C)
Refractive Index n 20/D 1.430(lit.)
pH 7 (200g/l, H2O, 20℃)
Log P -1.010
How is Dimethylformamide classified and handled safely? Learn More
Danger
GHS07· Irritant GHS08· Health Hazard GHS02· Flammable GHS06· Toxic GHS05· Corrosive
Hazard Statements
H226 Flammable liquid and vapor
H303 May be harmful if swallowed
H312 Harmful in contact with skin
H313 May be harmful in contact with skin
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
Which trade and regulatory codes apply to Dimethylformamide?
HS Code 29241990
UN Number 2265
ADR Class 3
Packing Group III
Storage Class 3 - Flammable liquids
WGK (Germany) 1