Diethylformamide

Diethylformamide (CAS 617-84-5), abbreviated DEF, is a high-boiling polar aprotic solvent.

Where is Diethylformamide used?

• Pharmaceutical manufacturing: process solvent for active ingredient synthesis
• Polymer and resin processing: dissolves or disperses specialty polymers
• Printing and packaging: incorporated into ink formulations and surface treatment processes requiring a stable, slow-evaporating solvent
• Fine chemical synthesis: reaction solvent where polarity and boiling point influence reaction selectivity
• It functions as a reaction medium and carrier solvent where controlled solvation and thermal stability are required.

Good to know: Used in purification steps where a high-boiling amide solvent is needed with lower toxicity concerns than DMF. Buyers sourcing for pharmaceutical applications should confirm GMP compliance and batch documentation with the supplier.

Commercial specifications

• Purity typically 99% or higher
• Clear liquid in drums and IBC containers; bulk quantities available