Diethylformamide

Diethylformamide (CAS 617-84-5), commonly abbreviated as DEF, is a high-boiling polar aprotic solvent used across pharmaceutical synthesis, polymer processing, and specialty chemical manufacturing.

It functions as a reaction medium and carrier solvent where controlled solvation and thermal stability are required. In pharmaceutical manufacturing, DEF serves as a process solvent for active ingredient synthesis.

It is utilized in purification steps where a high-boiling amide solvent is needed with lower toxicity concerns than DMF. Polymer and resin processors use it to dissolve or disperse specialty polymers.

This solvent is ideal for compounding and coating operations. In printing and packaging, DEF is incorporated into ink formulations and surface treatment processes that require a stable, slow-evaporating solvent.

This helps to control drying profiles effectively. It also functions as a reaction solvent in fine chemical synthesis where precise control over polarity and boiling point influences reaction selectivity.

DEF is supplied as a clear liquid in drums and IBC containers, with bulk quantities available for industrial procurement. Technical grade is the standard commercial offering for most industrial uses.

Purity specifications are typically at 99% or higher. Buyers sourcing for pharmaceutical applications should confirm GMP compliance and batch documentation with the supplier to ensure quality standards.