Diethyl malonate

CAS Number
105-53-3
EC Number
203-305-9
FEMA Number
FEMA 2375
Abbreviation
DEM

What is Diethyl malonate?

Diethyl malonate (CAS 105-53-3), also known as DEM or malonic ester, is a diester used as a synthetic intermediate and flavoring agent. FEMA 2375.

Where is Diethyl malonate used?

  • Pharmaceuticals: carbon-chain extender in barbiturates, amino acids and other APIs
  • Agrochemicals: intermediate for herbicides and insecticides
  • Flavor and fragrance: precursor to fruity aroma compounds
  • Personal care: carrier solvent and reactive intermediate
  • Its active methylene group makes it a building block for aroma compounds.

Commercial specifications

  • Purity 99% and above typical for synthesis grade
  • Clear liquid in drums, IBCs and bulk tankers

Other Names (Synonyms)

Diethyl propanedioate|Ethyl malonate|Malonic ester|Propanedioic acid, diethyl ester|1,3-diethyl propanedioate|Carbethoxyacetic ester|Malonic acid, diethyl ester|Propanedioic acid, 1,3-diethyl ester|DEM

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What are the physical properties of Diethyl malonate?

Melting Point -50 °C
Boiling Point 199 °C
Density 1.017336 g/cm³ @ Temp: 55.00 °C
Flash Point 212 °F
Appearance colourless liquid
Color colourless liquid
Odor Sweet ester odor
Form Liquid
Water Solubility Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Vapor Pressure 1 mm Hg ( 40 °C)
Refractive Index n 20/D 1.413(lit.)
Log P 0.96 at 20℃

How is Diethyl malonate classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H227 Combustible liquid
H319 Causes serious eye irritation
H402 Harmful to aquatic life

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P403 Store in a well-ventilated place.

Which trade and regulatory codes apply to Diethyl malonate?

HS Code 29171910
Storage Class 10 - Combustible liquids
WGK (Germany) 1
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