Solvents
REACH
Dimethylacetamide
CAS Number
127-19-5
EC Number
204-826-4
Abbreviation
DMAc
Industries: Pharma & Healthcare
What is Dimethylacetamide?
Dimethylacetamide (CAS 127-19-5), commonly known as DMAc or DMAC, is a high-boiling polar aprotic solvent used in pharmaceutical manufacturing, fiber production, and specialty chemical processing.
Where is Dimethylacetamide used?
- Pharmaceutical manufacturing: reaction solvent and crystallization medium for APIs, including antibiotics and oncology compounds
- Fiber and membrane production: dissolves polyacrylonitrile and aramid polymers for wet-spinning, carbon fiber precursors and filtration membranes
- Polyurethane films and coatings: process solvent enabling uniform dispersion of high-molecular-weight resins
- In agrochemical and specialty chemical synthesis it supports reactions requiring a stable, high-boiling, inert medium.
Good to know: Often categorized as an ICH Q3C Class 2 solvent. Moisture content and purity levels are typically specified to meet the requirements of regulated environments.
Commercial specifications
- Clear liquid in drums, IBCs, and bulk tanker quantities
- Technical grade and pharmaceutical-grade specifications
- Moisture content and purity levels specified for regulated environments
Other Names (Synonyms)
N,N-Dimethyl acetamide|DMAC|Acetamide, N,N-dimethyl-|Dimethylamide acetate|N,N-Dimethylethanamide
What are the physical properties of Dimethylacetamide?
Melting Point -18.59 °C
Boiling Point 163-165 °C
Density 0.9366 g/cm³ @ Temp: 25 °C
Flash Point 158 °F
Appearance colourless liquid with a faint ammonia odour
Color Colorless to yellowish
Odor Faint ammonia odor
Form Liquid
Water Solubility miscible
Vapor Pressure 40 mm Hg ( 19.4 °C)
Refractive Index n 20/D 1.439(lit.)
pH 4 (200g/l, H2O, 20℃)
Log P -0.77 at 25℃
How is Dimethylacetamide classified and handled safely? Learn More
Danger
GHS07· Irritant GHS08· Health Hazard GHS06· Toxic
Hazard Statements
H227 Combustible liquid
H303 May be harmful if swallowed
H312 Harmful in contact with skin
H313 May be harmful in contact with skin
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Which trade and regulatory codes apply to Dimethylacetamide?
HS Code 29241900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
WGK (Germany) 2