2,2-dimethoxypropane
Description
2,2-Dimethoxypropane (CAS 77-76-9), commonly known as DMP or acetone dimethyl acetal, is a reactive solvent and dehydrating agent used across pharmaceutical, biotech, and specialty chemical manufacturing.
It functions primarily as a water scavenger and protecting group reagent, enabling moisture-sensitive reactions and synthesis steps that require controlled anhydrous conditions.
In pharmaceutical synthesis, DMP protects carbonyl and hydroxyl groups during multi-step API manufacturing, reducing side reactions and improving yield consistency for manufacturers.
Biotech and life sciences laboratories use it as a rapid chemical dehydrant for biological sample preparation, particularly in electron microscopy tissue processing where water removal must be precise.
As a flavoring intermediate, acetone dimethyl acetal contributes to the production of certain aroma compounds where controlled acetal chemistry is required for the final product.
It also functions as a solvent in reactions where conventional polar aprotic solvents are unsuitable due to moisture sensitivity. This makes it a versatile tool in complex chemical synthesis.
2,2-Dimethoxypropane is supplied as a clear liquid in standard drum and IBC quantities, with bulk availability for industrial-scale procurement. Technical grade is the most common commercial specification.
High-purity grades are available to meet pharmaceutical and analytical laboratory requirements. Buyers should confirm purity thresholds and water content specifications with suppliers as a critical quality parameter.
Physical Properties
| Melting Point | -47 °C |
| Boiling Point | 83 °C |
| Density | 0.86199 g/cm³ (solid) @ Temp: 90 °C; Press: 750 Torr |
| Flash Point | 12 °F |
| Appearance | colourless liquid |
| Color | Clear colorless |
| Form | Liquid |
| Water Solubility | 18 g/100 mL (25 ºC) |
| Vapor Pressure | 60 mm Hg ( 15.8 °C) |
| Refractive Index | n 20/D 1.378(lit.) |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29110000 |
| UN Number | 1993 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 2 |
Documentation
Other Names
Acetone dimethyl acetal|Propane, 2,2-dimethoxy-|Acetone dimethyl ketal|66P41R0030|RefChem:81029|DMP
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