1,2-dimethoxyethane

1,2-Dimethoxyethane (CAS 110-71-4), commercially known as monoglyme or DME, is an ether-based solvent used in pharmaceutical synthesis, polymer chemistry and electrochemical applications.

Where is 1,2-dimethoxyethane used?

• Pharmaceutical manufacturing: supports Grignard reactions
• Organolithium chemistry and moisture-sensitive syntheses requiring a stable, non-protic solvent
• Battery and energy storage: co-solvent or primary electrolyte solvent in lithium-ion and lithium-metal cell formulations
• Polymer chemistry: controlled polymerizations, including anionic and ring-opening
• Palladium-catalyzed cross-coupling: reaction medium whose chelating behavior stabilizes catalyst systems and improves yields
• Its coordination with metal ions and dissolution of reactive intermediates make it a preferred solvent in demanding synthesis environments.

Good to know: Anhydrous DME is used where strict moisture control is critical to reaction outcomes.

Commercial specifications

• Packaging: drums to IBC containers and bulk quantities
• High-purity grades for battery electrolyte applications available from select suppliers