Triethyl orthoformate

Triethyl orthoformate (CAS 122-51-0), also known as ethyl orthoformate and abbreviated as TEOF, is a reactive intermediate.

Where is Triethyl orthoformate used?

• Pharmaceutical synthesis: protecting group reagent, alkylating agent and condensation reagent in multi-step organic synthesis
• Agrochemical manufacturing: introduction of orthoester functionality during synthesis of active pharmaceutical ingredients, particularly antimicrobials and antiviral compounds
• Printing inks and coatings: crosslinking agent and moisture scavenger that improves film stability and shelf life in moisture-sensitive systems
• Flavour and fragrance: synthesis of aroma compounds
• Personal care: preservative booster and intermediate in the preparation of conditioning actives

Commercial specifications

• Purity levels of 98% and above are standard for synthesis-grade supply
• Technical and high-purity grades; pharmaceutical-grade material meets specifications relevant to GMP manufacturing environments
• Clear liquid in standard packaging ranging from drums to ISO containers for bulk procurement