Diethyl sulfate
CAS Number
64-67-5
EC Number
200-589-6
Abbreviation
DES
What is Diethyl sulfate?
Diethyl sulfate (CAS 64-67-5), also known as DES, is a reactive diethyl ester of sulfuric acid used industrially as an ethylating agent.
Where is Diethyl sulfate used?
- Pharmaceutical synthesis: alkylation of active ingredients and intermediates
- Agrochemicals: manufacture of ethylated herbicide and pesticide intermediates
- Personal care: production of ethylated surfactants and conditioning agents
- It also serves as a solvent and carrier in select chemical processes.
Good to know: Reactivity profile must be compatible with the target substrate. Buyers sourcing for pharmaceutical intermediate production should confirm supplier documentation and applicable regulatory requirements for their jurisdiction.
Commercial specifications
- Purity: 99% minimum
- Liquid, in drum and IBC quantities
Other Names (Synonyms)
Diethyl sulphate|Sulfuric acid, diethyl ester|Diethyl tetraoxosulfate|Diethylester kyseliny sirove|K0FO4VFA7I|Ethyl sulfate (Et2SO4)|Ethyl sulfate|DES
What are the physical properties of Diethyl sulfate?
Melting Point -25 °C
Boiling Point 90-91 °C @ Press: 12 Torr
Density 1.172 g/cm³ @ Temp: 25 °C
Flash Point 173 °F
Appearance colourless oily liquid
Color Clear
Odor char. faint ether odor, irritating after-effect
Form Liquid
Water Solubility 5 g/L (20 ºC)
Vapor Pressure <0.01 mm Hg ( 20 °C)
Refractive Index n 20/D 1.399(lit.)
How is Diethyl sulfate classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS07· Irritant GHS08· Health Hazard GHS06· Toxic
Hazard Statements
H302 Harmful if swallowed
H311 Toxic in contact with skin
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
Which trade and regulatory codes apply to Diethyl sulfate?
HS Code 29209090
UN Number 1594
ADR Class 6.1
Packing Group II
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
WGK (Germany) 3