Preservatives & Biocides
REACH
Diazolidinyl urea
CAS Number
78491-02-8
EC Number
278-928-2
What is Diazolidinyl urea?
Diazolidinyl urea (CAS 78491-02-8), also known commercially as Germall 11, is a formaldehyde-releasing preservative used in personal care and pharmaceutical formulations.
Where is Diazolidinyl urea used?
- Cosmetics: broad-spectrum antimicrobial protection against bacteria, yeast, and mold in rinse-off and leave-on lotions, shampoos, and conditioners
- Liquid and gel-based personal care: water solubility allows incorporation without disrupting emulsion stability
- Pharmaceutical topicals: creams and ointments meet preservation efficacy requirements under challenge testing
- It is frequently paired with parabens or other co-preservatives to broaden coverage and reduce use levels.
Commercial specifications
- Conforms to USP and BP monographs
- Packaging from kilogram quantities to bulk drums
Other Names (Synonyms)
N,N'-Bis(hydroxymethyl) urea|Germall 11|Imidazolidinyl urea 11|N9VX1IBW6K|H5RIZ3MPW4|Germall II|Germaben II-E
What are the physical properties of Diazolidinyl urea?
Boiling Point 421.04°C (rough estimate)
Density 1.4734 (rough estimate)
Appearance white powder
Color White to Off-White
Form Solid
Water Solubility 1000g/L at 20℃
Vapor Pressure 0Pa at 20℃
Refractive Index 1.6590 (estimate)
Log P 0.9 at 20℃
How is Diazolidinyl urea classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
Which trade and regulatory codes apply to Diazolidinyl urea?
HS Code 29339900
WGK (Germany) 2