Solketal

Solketal (CAS 100-79-8), also known as Glycerol dimethylketal, is a cyclic acetal derived from glycerol; used as a solvent, carrier, and chemical intermediate.

Where is Solketal used?

• Pharmaceutical manufacturing: solvent and carrier for active ingredients, improving solubility and stability in oral and topical drug formulations
• Pharmaceutical manufacturing: chiral building block in the synthesis of antitumor, anti-inflammatory, and antiviral drugs
• Cosmetics: skin-conditioning carrier and co-solvent in serums, creams, and emulsions
• Cosmetics: chiral building block in the synthesis of cosmetic ingredients such as fatty acid esters and emulsifiers
• Polymer and resin chemistry: reactive intermediate and crosslinking agent in specialty polyols and industrial coatings
• Polymer and resin chemistry: modifier in polyesters, polyurethanes, polyacrylates, and polyethers via condensation reactions with water elimination
• Synthesis of mono-, di- and triglycerides
• Fuel blending: stabilizer that improves cold-flow properties and reduces oxidative degradation in biodiesel

Good to know: Pharmaceutical-grade material meets USP and BP specifications; technical-grade product serves polymer and fuel applications.

Formulation notes

• Incompatible with acids and strong oxidizing agents.
• Good solvent for both polar and non-polar compounds.
• Slow evaporation solvent derived from glycerin.

Typical specification

• Supplied in technical grade and reagent grade, typically at purity of at least 98%.

Regulatory status

• Registered under EU REACH with EC/List-No. 202-888-7.
• INCI name is Isopropylideneglycerol.
• Classified as H319 causing serious eye irritation and H361d suspected of damaging the unborn child.

Storage, packaging and handling

• Store in a cool, dry, well-ventilated area with containers kept tightly closed.
• Also supplied in IBC tanks and customized packaging.

Frequently asked questions about Solketal

What is the typical water content of Solketal?

Water content (Karl Fischer) is at most 0.3%.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.