Solketal
Description
Solketal (CAS 100-79-8), also known as Glycerol dimethylketal, is a cyclic acetal derived from glycerol used as a solvent, carrier, and chemical intermediate across pharmaceutical, cosmetic, and polymer applications.
Its low toxicity profile and biodegradable character make it a preferred alternative to conventional solvents in formulations where regulatory compliance and sustainability drive sourcing decisions.
In pharmaceutical manufacturing, this compound functions as a solvent and carrier for active ingredients, improving solubility and stability in oral and topical drug formulations.
Cosmetic formulators incorporate it as a skin-conditioning carrier and co-solvent in serums, creams, and emulsions where clean-label positioning is a priority for the brand.
In polymer and resin chemistry, it acts as a reactive intermediate and crosslinking agent, particularly in the synthesis of specialty polyols and high-performance industrial coatings.
It also serves as a stabilizer in fuel blending applications, where it improves cold-flow properties and reduces oxidative degradation in modern biodiesel formulations.
The material is supplied as a clear liquid in drum and IBC quantities suited to industrial procurement. Pharmaceutical-grade material is available to meet USP and BP specifications.
Technical-grade product serves polymer and fuel applications. Purity levels typically range from 98% to 99%+ depending on the specific grade and the intended industrial end use.
Physical Properties
| Melting Point | -26.4 °C |
| Boiling Point | 188 °C |
| Density | 1.06 g/cm³ |
| Flash Point | 176 °F |
| Appearance | clear colourless liquid |
| Color | Clear colorless |
| Form | Liquid |
| Water Solubility | miscible |
| Vapor Pressure | 34Pa at 20℃ |
| Refractive Index | n 20/D 1.434 |
| pH | 4.0-7.5 (H2O) |
| Log P | 0.3 at 20℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29329970 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 2 |
Documentation
Other Names
2,2-Dimethyl-1,3-dioxolane-4-methanol|Glycerol dimethylketal|Dioxolan|Isopropylidene glycerol|Glycerol acetonide|2,3-Isopropylideneglycerol|1,3-Dioxolane-4-methanol, 2,2-dimethyl-|2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane
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