SoleChem

Solketal

Solvents Plastics & Polymers
CAS
100-79-8
EC
202-888-7
Mol. Weight
132.16 g/mol

Description

Solketal (CAS 100-79-8), also known as Glycerol dimethylketal, is a cyclic acetal derived from glycerol used as a solvent, carrier, and chemical intermediate across pharmaceutical, cosmetic, and polymer applications.

Its low toxicity profile and biodegradable character make it a preferred alternative to conventional solvents in formulations where regulatory compliance and sustainability drive sourcing decisions.

In pharmaceutical manufacturing, this compound functions as a solvent and carrier for active ingredients, improving solubility and stability in oral and topical drug formulations.

Cosmetic formulators incorporate it as a skin-conditioning carrier and co-solvent in serums, creams, and emulsions where clean-label positioning is a priority for the brand.

In polymer and resin chemistry, it acts as a reactive intermediate and crosslinking agent, particularly in the synthesis of specialty polyols and high-performance industrial coatings.

It also serves as a stabilizer in fuel blending applications, where it improves cold-flow properties and reduces oxidative degradation in modern biodiesel formulations.

The material is supplied as a clear liquid in drum and IBC quantities suited to industrial procurement. Pharmaceutical-grade material is available to meet USP and BP specifications.

Technical-grade product serves polymer and fuel applications. Purity levels typically range from 98% to 99%+ depending on the specific grade and the intended industrial end use.

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Physical Properties

Melting Point -26.4 °C
Boiling Point 188 °C
Density 1.06 g/cm³
Flash Point 176 °F
Appearance clear colourless liquid
Color Clear colorless
Form Liquid
Water Solubility miscible
Vapor Pressure 34Pa at 20℃
Refractive Index n 20/D 1.434
pH 4.0-7.5 (H2O)
Log P 0.3 at 20℃

Safety & Handling (Learn More)

Warning GHS07 GHS09
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
H411 Toxic to aquatic life with long lasting effects
Precautionary Statements
P264 Wash … thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P391 Collect spillage.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P302+P352 IF ON SKIN: Wash with plenty of water.
P332+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29329970
Storage Class 10 - Combustible liquids
WGK (Germany) 2

Documentation

Other Names

2,2-Dimethyl-1,3-dioxolane-4-methanol|Glycerol dimethylketal|Dioxolan|Isopropylidene glycerol|Glycerol acetonide|2,3-Isopropylideneglycerol|1,3-Dioxolane-4-methanol, 2,2-dimethyl-|2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane

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