1,4-dioxane

CAS Number
123-91-1
EC Number
204-661-8
Chemical Formula
C4H8O2
Molecular Weight
88.11 g/mol

Description

1,4-Dioxane (CAS 123-91-1) is a cyclic ether solvent used across chemical manufacturing, laboratory research, and industrial processing. It functions as a high-solvency carrier for resins and cellulose derivatives. This versatile compound is effective for a broad range of organic compounds where other solvents underperform. In pharmaceutical and chemical synthesis, it serves as a reaction solvent and extraction medium.

It is particularly useful in processes requiring miscibility with both water and organic phases. Personal care manufacturers monitor it as a trace contaminant in ethoxylated ingredients for safety. The chemical acts as a reference standard for quality control and regulatory compliance testing. In laboratory settings, it is used as a scintillation solvent and as a stabilizer carrier.

It is also utilized in analytical-grade preparations for various research applications. Food and fragrance applications involve its use as a trace flavoring reference compound for testing. Despite these niche uses, its primary commercial demand remains in industrial solvent and synthesis roles. The product is supplied as a colorless liquid in drums and bulk containers.

Standard grades include technical, reagent, and HPLC-grade, with anhydrous specifications available. These are ideal for moisture-sensitive synthesis applications in controlled environments. Stabilized and unstabilized variants are both commercially available for purchase. Grade selection is typically driven by specific end-use process requirements and stability needs.

Other Names (Synonyms)

tetrahydro-para-dioxin|tetrahydro-p-dioxin|tetrahydro-1,4-dioxin|p-Dioxane|glycol ethylene ether|dioxane-1,4|Dioxan|Diethylene ether

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 11.80 °C
Boiling Point 101.1 °C @ Press: 760 Torr
Density 1.0337 g/cm³ @ Temp: 20 °C
Flash Point 54 °F
Appearance colourless liquid
Color APHA: ≤20
Odor Mild ether-like odor detectable at 0.8 to 172 ppm (mean = 12 ppm)
Form Solution
Water Solubility SOLUBLE
Vapor Pressure 27 mm Hg ( 20 °C)
Refractive Index n 20/D 1.422(lit.)
pH 6-8 (500g/l, H2O, 20℃)
Log P -0.42 at 20℃

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS07· Irritant GHS08· Health Hazard GHS06· Toxic

Hazard Statements

H225 Highly Flammable liquid and vapor
H313 May be harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.

Trade & Regulatory

HS Code 29329900
UN Number 1993
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 3
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