Amines REACH

Spermidine

CAS Number
124-20-9
EC Number
204-689-0
Abbreviation
SPD

What is Spermidine?

Spermidine (CAS 124-20-9), also abbreviated SPD, is a naturally occurring polyamine sourced from plant and microbial origins; both synthetic and natural-extract forms exist.

Where is Spermidine used?

  • Cosmetics and personal care: anti-aging serums and scalp treatments supporting hair follicle longevity and skin renewal
  • Pharmaceutical and nutraceutical: active ingredient in longevity-focused dietary supplements, capsules and functional foods
  • Biotechnology: reagent in cell culture media, nucleic acid stabilization protocols and enzyme activity studies
  • Food-grade: functional food fortification via wheat germ extract standardized to spermidine content
  • It also serves as a bioactive ingredient targeting cellular renewal pathways and a biochemical reagent in research workflows.

Good to know: The trihydrochloride salt in powder form offers improved stability over the free base. Grades include research-grade (high-purity ≥98%) and cosmetic/nutraceutical-grade material.

Commercial specifications

  • Research-grade: high-purity ≥98%
  • Cosmetic/nutraceutical-grade material
  • Wheat germ extract standardized to defined spermidine content

Other Names (Synonyms)

Spermidin|N-(gamma-Aminopropyl)tetramethylenediamine|N-(4-Aminobutyl)-1,3-diaminopropane|N-(3-aminopropyl)butane-1,4-diamine|N-(3-Aminopropyl)-4-aminobutylamine|N-(3-Aminopropyl)-1,4-diaminobutane|N-(3-Aminopropyl)-1,4-butanediamine|4-Azaoctane-1,8-diamine|SPD

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What are the physical properties of Spermidine?

Melting Point <25 °C
Boiling Point 128-130 °C
Density 1.00054 g/cm³ @ Temp: 45 °C
Flash Point >230 °F
Appearance Colorless clear liquid
Color Clear colorless
Odor Ichtyal, ammoniacal
Form Liquid After Melting
Water Solubility Miscible with water, ethanol and ether.
Refractive Index n 20/D 1.479(lit.)
pH 12.0-13.5 (25℃, 1M in H2O)

How is Spermidine classified and handled safely? Learn More

Danger
GHS05· Corrosive

Hazard Statements

H314 H314
H318 H318

Precautionary Statements

P260 P260
P264 P264
P280 P280
P316 P316

Which trade and regulatory codes apply to Spermidine?

HS Code 29212900
UN Number 2735
ADR Class 8
Packing Group II
WGK (Germany) 3
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