Vitamin B5 Pantethine

Vitamin B5 Pantethine (CAS 16816-67-4) is the disulfide form of pantetheine, the active coenzyme precursor derived from pantothenic acid within the Vitamin B5 family. Distinct from the more common calcium pantothenate, pantethine carries a higher degree of biological activity at the cellular level, making it a recognised ingredient of choice for formulators requiring a functionally differentiated B5 source across nutraceutical, pharmaceutical, and cosmetic applications. In the nutraceuticals and dietary supplements sector, pantethine is listed under the name pantethine in Annex II of Directive 2002/46/EC, confirming its status as an approved vitamin source for use in food supplement formulations marketed across the EU. Formulators incorporating Vitamin B5 into supplement products may reference the authorised EU health claims established under Regulation (EC) No 432/2012, which recognise that Vitamin B5 contributes to normal energy-yielding metabolism, normal mental performance, normal synthesis of steroid hormones and vitamin D, and the reduction of tiredness and fatigue.

For pharmaceutical and healthcare manufacturers, pantethine is supplied to standards aligned with recognised pharmacopoeial requirements. Buyers specifying material for finished-dose applications should confirm applicable grade requirements — food-grade and pharma-grade material is available — and are encouraged to request certificates of analysis, HPLC purity data, and full regulatory dossiers as part of standard procurement due diligence. In personal care and cosmetics, pantethine functions as a humectant and moisturising active, supporting skin barrier hydration and conditioning. Its softening and plasticising properties make it a useful functional ingredient in leave-on formulations, hair care products, and topical preparations where moisture retention and substrate flexibility are technical objectives. It may also contribute to cross-linking interactions relevant to film-forming cosmetic systems.

Pantethine is typically handled as a hygroscopic solid and should be stored under controlled conditions — cool, dry, and away from moisture and direct light — to preserve stability throughout the supply chain. Shelf life and storage guidance are provided on product-specific technical datasheets. SoleChem supplies Vitamin B5 Pantethine in bulk quantities to industrial buyers across Europe. Standard packaging configurations include 25 kg drums or fibre cartons for volume orders, with smaller pack sizes available for development batches or lower-volume procurement needs. Lot traceability, SDS, and supporting technical documentation are provided as standard.

Buyers working across supplement manufacturing, pharmaceutical compounding, or cosmetic formulation are invited to contact SoleChem's technical sales team to discuss grade suitability, available documentation, lead times, and supply terms for Vitamin B5 Pantethine.