Calcium thioglycolate

CAS Number
37457-75-3

What is Calcium thioglycolate?

Calcium thioglycolate (CAS 37457-75-3) is the calcium salt of thioglycolic acid, used primarily as a depilatory and hair-waving agent in personal care formulations.

Where is Calcium thioglycolate used?

  • Personal care: depilatory creams and lotions that disrupt hair protein at the skin surface
  • Hair care: active reducing agent in cold wave and permanent wave formulations
  • Textile processing: reducing agent for wool treatments, improving fiber softness and dye receptivity
  • Leather processing: unhairing agent that loosens hair and helps remove the epidermis from hides before tanning
  • It breaks disulfide bonds in keratin, enabling controlled hair removal.

Good to know: Unlike sodium or potassium thioglycolate, it allows restructuring without strongly alkaline alternatives and clean removal with minimal irritation.

Commercial specifications

  • Cosmetic-grade purity levels typically documented to meet formulator requirements

Other Names (Synonyms)

(2-(Mercapto-kappaS)acetato(2-)-kappaO)calcium|[2-(mercapto-κs)acetato(2-)-κo]calcium|Calcium 2-sulfidoacetate

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How is Calcium thioglycolate classified and handled safely? Learn More

Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H301 Toxic if swallowed [Danger Acute toxicity, oral]
H312 Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 Causes skin irritation [Warning Skin corrosion/irritation]
H317 May cause an allergic skin reaction [Warning Sensitization, Skin]
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