alpha-D-glucose pentaacetate

CAS Number
604-68-2
EC Number
210-073-2
FEMA Number
FEMA 2524

What is alpha-D-glucose pentaacetate?

Alpha-D-glucose pentaacetate (CAS 604-68-2), also known as pentaacetyl-alpha-D-glucose, is a fully acetylated glucose derivative used primarily as a pharmaceutical intermediate and specialty chemical in fine chemical synthesis.

Where is alpha-D-glucose pentaacetate used?

  • Pharmaceutical manufacturing: key starting material for synthesis
  • Synthesis of nucleoside analogues, glycosylated drug compounds and other carbohydrate-based active pharmaceutical ingredients
  • Protected glucose building block enabling selective glycosylation without additional protection steps
  • Stereoselective glycosylation precursor due to its well-defined anomeric configuration
  • Personal care: evaluated as a stabilizing and moisturizing agent
  • Research and specialty chemical producers use it as a reference standard or reagent-grade intermediate in carbohydrate chemistry workflows.

Good to know: Its well-defined anomeric configuration makes it the preferred precursor for stereoselective glycosylation; this precision is critical to API purity and regulatory compliance.

Commercial specifications

  • Packaging from laboratory-scale quantities up to bulk orders

Other Names (Synonyms)

alpha-D-Glucopyranose, pentaacetate|Pentaacetyl-alpha-D-glucose|1,2,3,4,6-Penta-O-acetyl-alpha-D-glucopyranose|Penta-O-acetyl-alpha-D-glucopyranose|1CS424NS93|α-D-Glucopyranose, 1,2,3,4,6-pentaacetate|Glucopyranose, pentaacetate, α-D-|α-D-Glucopyranose, pentaacetate

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What are the physical properties of alpha-D-glucose pentaacetate?

Melting Point 113.3 °C
Boiling Point ~0.115 °C (approx) @ Press: 3 x 10-4 Torr
Density 1.3984 (rough estimate)
Appearance white to light yellow crystal powde
Color White to off-white
Odor at 100.00 %. odorless
Form Powder
Water Solubility < 5 G/L (25 ºC)
Vapor Pressure 0-0Pa at 20-50℃
Refractive Index 105.5 ° (C=1.5, MeOH)
Log P 1.87 at 25℃ and pH5.7

How is alpha-D-glucose pentaacetate classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed
H317 May cause an allergic skin reaction

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.

Which trade and regulatory codes apply to alpha-D-glucose pentaacetate?

HS Code 29224210
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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