Alpha cyclodextrin
Description
Alpha cyclodextrin (CAS 10016-20-3), also known as Alfadex, is a cyclic oligosaccharide derived from starch that forms inclusion complexes with a wide range of guest molecules. This encapsulation capability makes it a functional ingredient for stabilizing actives.
It is used for masking unwanted properties and improving ingredient delivery across multiple industries. In pharmaceuticals, it improves the bioavailability of poorly soluble APIs by encapsulating them within its cavity.
This enables more effective oral and topical drug formulations. Food manufacturers use it to stabilize flavors and fat-soluble vitamins against oxidation and volatility loss during processing and shelf storage.
In personal care formulations, it encapsulates fragrance compounds and active ingredients, extending scent longevity. It also improves controlled release in skin and hair products while functioning as a dietary fiber ingredient.
In functional food and nutraceutical applications, it supports fat absorption management. Alpha cyclodextrin is supplied as a white crystalline powder available in food-grade and pharmaceutical-grade material.
The pharmaceutical grade conforms to USP, Ph. Eur., and BP monographs. Bulk quantities are standard for industrial procurement, with high-purity grades required for regulated food and drug applications.
Physical Properties
| Melting Point | >278 °C (dec.)(lit.) |
| Boiling Point | 784.04°C (rough estimate) |
| Density | 1.521 g/cm³ (solid) |
| Appearance | White crystalline powder |
| Color | White |
| Odor | at 100.00?%. odorless |
| Form | powder |
| Water Solubility | Soluble in water at 1%(w/v) |
| Refractive Index | 1.7500 (estimate) |
| pH | 5.0-8.0 (1% in solution) |
| Log P | -7.77 |
Trade & Regulatory
| HS Code | 29400090 |
| WGK (Germany) | 3 |
Documentation
Other Names
Alfadex|α-cyclodextrin|(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol|alpha-cyclodextrin|α-CD
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