Hydroxypropyl beta cyclodextrin

Hydroxypropyl beta cyclodextrin (CAS 128446-35-5), also known as hydroxypropyl betadex and abbreviated HPBCD, is a modified cyclic oligosaccharide. It is used in pharmaceutical, food, and cosmetic manufacturing.

Where is Hydroxypropyl beta cyclodextrin used?

• Pharmaceutical drug formulation: enables injectable, oral, and nasal delivery systems for APIs with low aqueous solubility
• Cosmetics and personal care: stabilizes fragrance compounds, vitamins, and botanical extracts in creams, serums, and rinse-off products
• Food and nutraceuticals: encapsulates flavors, colorants, and functional ingredients to mask off-notes or protect against oxidative degradation
• Biotechnology and life sciences: cholesterol-extracting agent in cell membrane research and solubilizer in assay development
• Its primary commercial function is encapsulating poorly soluble or unstable active ingredients within its cavity, improving solubility, bioavailability, and shelf stability.

Commercial specifications

• Pharmaceutical-grade specifications include USP, Ph. Eur., and BP
• Degree of substitution is part of the product specification
• Food-grade material is commercially available for flavor and nutraceutical applications requiring high purity and stability