Beta cyclodextrin

Beta cyclodextrin (CAS 7585-39-9), also known as Betadex and approved as E459, is a cyclic oligosaccharide derived from starch that encapsulates guest molecules within its hydrophobic cavity.

Where is Beta cyclodextrin used?

• Pharmaceuticals: enhances solubility and bioavailability of poorly water-soluble APIs, enabling more consistent drug delivery in oral and topical formulations
• Food: under E459 approval protects flavors and aromas from oxidation and volatilization, extending shelf life of seasonings, encapsulated flavors and functional food ingredients
• Personal care: stabilizes fragrance compounds and active ingredients in creams, deodorants and hair care products, reducing degradation during storage and use
• It also functions as a chelating agent where metal ion sequestration is needed, preventing rancidity or discoloration in sensitive chemical and cosmetic mixtures.
• Used to reduce cholesterol levels in milk fat.
• In eye drop formulations, forms water-soluble complexes with lipophilic drugs such as corticosteroids.
• Used to encapsulate omega-3 and omega-6 fatty acids from fish oils and algae extracts, yielding an odorless powder that protects the fats from oxidation.
• Can alleviate gastrointestinal drug irritation and prevent drug-drug and drug-excipient interactions.

Formulation notes

• When directly compressed, a lubricant such as 0.1% w/w magnesium stearate is required.
• Stable but incompatible with strong oxidizing agents.

Typical specification

• pH between 5.0 and 8.0.
• Heavy metals content below 10 ppm.
• Loss on drying of not more than 14.0%.
• Assay between 98.0% and 102.0%.

Regulatory status

• In the EU, approved as a food additive with a maximum level of 1 g/kg of food.
• Nephrotoxic and should not be used in parenteral formulations.

Storage, packaging and handling

• Should be stored at room temperature.

Frequently asked questions about Beta cyclodextrin

In which oral tablet processes can beta cyclodextrin be used?

In oral tablet formulations, it can be used in both wet granulation and direct compression processes.

How does beta cyclodextrin function in cosmetic and chewing gum applications?

In the cosmetics industry, it is used in products such as detergents and perfumes for controlled release of fragrances. It acts as a molecular carrier enabling controlled release of flavor compounds in chewing gum, released gradually on chewing.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.