SoleChem

Propylene oxide

Solvents Biotechnology & Life Sciences
CAS
75-56-9
EC
200-879-2
Mol. Weight
58.08 g/mol

Description

Propylene oxide (CAS 75-56-9), commonly abbreviated as PO, is a reactive epoxide monomer and industrial solvent used across polymer manufacturing, sterilization, and chemical synthesis.

Methyl oxirane is the form referenced in many technical and regulatory contexts as a distinct search term. Its primary commercial role is as a building block for polyols and propylene glycols.

PO is the key feedstock for polyether polyols used in polyurethane foam production. This covers rigid insulation panels, flexible seating, and various automotive interiors for industrial manufacturing.

In food and pharmaceutical processing, it functions as a fumigant and sterilizing agent for spices and cocoa. It is also used for medical equipment where heat sterilization is not viable.

Propylene glycol, produced by hydration of PO, feeds into food-grade humectants and cosmetic carriers. It is also a primary component in modern antifreeze formulations and industrial coolants.

In biotechnology, PO is used as a fixative and dehydration agent in electron microscopy sample preparation. It is supplied as a liquid in bulk quantities, typically via ISO tank containers.

Standard commercial grades include polymer-grade and technical-grade specifications. Purity levels are commonly at 99.5% or higher for polyol synthesis applications and chemical manufacturing.

Buyers sourcing for food or pharmaceutical sterilization applications should confirm compliance with regional regulatory standards. Proper handling is required due to its low boiling point and volatility.

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Physical Properties

Melting Point -112.13 °C
Boiling Point 34.23 °C
Density 0.8 g/cm³
Flash Point −35 °F
Appearance Propylene oxide is a colorless liquid. Ethereal odor.
Color Clear
Odor Ethereal; characteristic; sweet, alcoholyc; like natural gas.
Form Liquid
Water Solubility 40 g/100 mL (20 ºC)
Vapor Pressure 29.43 psi ( 55 °C)
Refractive Index n 20/D 1.366(lit.)
Log P 0.030

Safety & Handling (Learn More)

Danger GHS02 GHS06 GHS08 GHS07 GHS05
Hazard Statements
H224 Extremely flammable liquid and vapor
H302 Harmful if swallowed
H311 Toxic in contact with skin
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H318 Causes serious eye damage
H319 Causes serious eye irritation
H330 Fatal if inhaled
H331 Toxic if inhaled
H332 Harmful if inhaled
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
H340 May cause genetic defects
H341 Suspected of causing genetic defects
H350 May cause cancer
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 In case of inadequate ventilation wear respiratory protection.
P316 Get emergency medical help immediately.
P317 Get emergency medical help.
P318 IF exposed or concerned, get medical advice.
P319 Get medical advice/attention if you feel unwell.
P320 Specific treatment is urgent (see … on this label).
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P317 Get emergency medical help.
P333+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P362+P364 Take off contaminated clothing and wash it before reuse.
P370+P378 Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P301+P330+P331 Rinse mouth. Do NOT induce vomiting.
P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29102000
UN Number 1280
ADR Class 3
Packing Group I
Storage Class 3 - Flammable liquids
WGK (Germany) 3

Documentation

Other Names

propene oxide|methyl oxirane|methyl ethylene oxide|2,3-epoxypropane|1,2-propylene oxide|1,2-epoxy propane|2-methyloxirane|Oxirane, methyl-|PO

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