Simethicone

CAS Number
8050-81-5
EC Number
617-098-1

What is Simethicone?

Simethicone (CAS 8050-81-5) is a mixture of polydimethylsiloxane and silicon dioxide used industrially and pharmaceutically as an antifoaming and defoaming agent.

Where is Simethicone used?

  • Pharmaceutical: antiflatulent tablets, suspensions and chewable formulations to reduce gastrointestinal gas discomfort
  • Food and beverage processing: process aid that suppresses foam during fermentation and cooking
  • Personal care and cosmetics: conditioning and smoothing agent in skin creams, lotions and hair care products
  • Industrial: fermentation bioreactors and chemical processing equipment where foam control affects yield and process efficiency
  • High-speed filling operations require foam suppression where excessive foam causes production losses.

Good to know: USP and NF grades are standard for pharmaceutical and food applications; food-grade specifications are also available for processing use.

Commercial specifications

  • 30% and 100% active material
  • Bulk supply in drums and intermediate bulk containers

Other Names (Synonyms)

Sentry Simethicone|Mylanta Gas Relief|Mylicon Infant's Drops|Sentry Simethicone Emulsion|RefChem:886342|3,3,5,5-tetramethyl-2,4-dioxa-3,5-disilahexane; silanedione|Antifoam A|DC Antifoam A

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What are the physical properties of Simethicone?

Melting Point 0 °C (32 °F)
Density 0.980 g/cm³
Flash Point >101°C
Appearance Viscous, greyish-white, opalescent liquid.
Color Colorless
Form emulsion
Vapor Pressure 5 mm Hg ( 20 °C)
Refractive Index n 20/D 1.406
Log P 3.404 (est)

How is Simethicone classified and handled safely? Learn More

Danger
GHS02· Flammable GHS07· Irritant

Hazard Statements

H225 Highly Flammable liquid and vapor
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Which trade and regulatory codes apply to Simethicone?

HS Code 3910000000
Storage Class 10 - Combustible liquids
WGK (Germany) 3
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