Chlorphenesin

Chlorphenesin (CAS 104-29-0), also known as p-chlorophenyl-alpha-glyceryl ether, is a synthetic antimicrobial active used across cosmetic and pharmaceutical formulations. It functions as a preservative and biocide, inhibiting microbial growth to extend product shelf life. In personal care, this compound is used as a preservative in rinse-off and leave-on products including moisturizers, cleansers, and hair care formulations. It is often used in combination with other preservatives to broaden the antimicrobial spectrum.

Pharmaceutical manufacturers incorporate it into topical preparations where controlled microbial protection is required without the regulatory burden of more restricted preservative systems. Its compatibility with a range of cosmetic actives makes it a practical option. Formulators developing paraben-free preservation systems frequently select this ingredient for its stability and efficacy. It is also evaluated as a pharmaceutical intermediate in select synthesis pathways targeting chlorinated glycerol ether derivatives.

The material is supplied as a white crystalline powder. Standard market grades include cosmetic/personal care grade and pharmaceutical-grade material, with suppliers typically offering documentation aligned to USP or in-house specifications. Packaging is available in kilogram quantities for development use through to bulk supply for commercial manufacturing. This ensures that both small-scale laboratories and large industrial facilities can source the material according to their specific production needs.