Hydroxyethylnitrosourea

Hydroxyethylnitrosourea (CAS 13743-07-2), also referenced as N-(2-hydroxyethyl)-N-nitrosourea, is a nitrosourea compound used primarily in pharmaceutical research and oncology drug development.

It functions as a DNA-alkylating reference agent and research intermediate in studies targeting cell proliferation and mutagenesis mechanisms. In pharmaceutical R&D, it serves as a reference standard.

It is used as a synthetic intermediate in the development of alkylating chemotherapeutic agents, particularly within nitrosourea-class drug programs. Biotechnology laboratories use it in controlled mutagenesis studies.

These studies investigate DNA damage response pathways and evaluate repair mechanisms in cell-based assay systems. It is also employed in preclinical screening protocols where nitrosourea-type compounds are benchmarked.

Contract research organizations sourcing nitrosourea intermediates for structure-activity relationship studies may evaluate this compound as a building block for analog synthesis in various programs.

Hydroxyethylnitrosourea is supplied as a solid, typically in small research-scale quantities reflecting its primary use in laboratory and preclinical settings. Material is available to research-grade specification.

Purity is confirmed by HPLC or NMR as standard for pharmaceutical intermediates. Buyers should confirm cold-chain and stability requirements with suppliers prior to procurement for safety.

Nitrosourea compounds require controlled storage conditions to maintain integrity. This ensures the material meets the necessary performance benchmarks required for sensitive pharmaceutical research applications.