N-butyl-N-nitrosourea

N-butyl-N-nitrosourea (CAS 869-01-2), also referenced in research procurement as N-Nitroso-N-butylurea, is a nitrosourea compound used primarily as a chemical carcinogen in controlled pharmaceutical and biomedical research settings.

Where is N-butyl-N-nitrosourea used?

• Preclinical oncology: establishing animal tumor models for evaluating anticancer drug candidates and treatment protocols
• Carcinogenesis research: gastric and bladder cancer models supporting development of new therapeutic compounds
• Genotoxicity and mutagenicity assays: reference compound requiring reproducible DNA alkylation activity for comparative studies
• Regulatory toxicology: positive control substance
• It functions as an alkylating agent, enabling researchers to induce targeted DNA damage in experimental models.

Good to know: Given regulatory considerations around nitrosourea compounds, buyers should confirm supplier compliance with applicable handling requirements.

Commercial specifications

• Solid, typically in small research-quantity formats
• Research-grade specifications for laboratory procurement