Alpha-GPC (L-Alpha-Glycerylphosphorylcholine)

Alpha-GPC (L-Alpha-Glycerylphosphorylcholine) (CAS 28319-77-9) is a naturally occurring choline-containing phospholipid compound of the choline vitamin-like nutrient family. Also known under the INN choline alfoscerate.

Where is Alpha-GPC (L-Alpha-Glycerylphosphorylcholine) used?

• Nutraceutical and dietary supplement: choline donor in cognitive support, sports nutrition and healthy ageing formulations
• Pharmaceutical and healthcare: active pharmaceutical ingredient in several European markets
• Personal care and cosmetic: humectant and skin-conditioning agent in serums, moisturisers and leave-on treatments
• It is also evaluated for mild preservative-supporting activity in certain multi-functional formulations.

Good to know: Derived from lecithin through enzymatic or chemical hydrolysis, it is a highly bioavailable choline source. Hygroscopic; packaging protects it from moisture uptake during storage and transit.

Commercial specifications

• Active content 50% or 99% L-Alpha-Glycerylphosphorylcholine
• 50% typically a hygroscopic powder or granule; 99% anhydrous crystalline grade
• Cold-water-soluble (CWS) formats for rapid dispersibility in aqueous matrices
• PhEur- or USP-aligned pharmaceutical-grade material with certificates of analysis, residual solvent profiles and heavy metal testing; Halal and Kosher certifications, non-GMO declarations and allergen statements available
• 25 kg fibre drums with inner polyethylene liner; 1 kg and 5 kg heat-sealed foil pouches