Calcium Folinate (leucovorin)

Calcium Folinate (leucovorin) (CAS 1492-18-8) is the calcium salt of folinic acid, a biologically active, reduced derivative of folic acid belonging to the Vitamin B9 family.

Where is Calcium Folinate (leucovorin) used?

• Pharmaceutical: injectable preparations, oral solid dosage forms such as tablets, and lyophilised formulations
• Nutraceuticals and dietary supplements: highly bioavailable B9 source
• Personal care and cosmetics: B-vitamin actives for skin and scalp preparations, water solubility supports incorporation into aqueous systems and leave-on or rinse-off formats
• It circumvents the conversion steps required by unmetabolised folic acid.

Good to know: Not listed in Annex II of Directive 2002/46/EC for use in food supplements in the EU; confirm the applicable regulatory framework for the target market prior to specification. Authorised EU health claims under Regulation (EC) No 432/2012 for Vitamin B9 include contributions to normal amino acid synthesis, blood formation, homocysteine metabolism, normal immune system function, and normal maternal tissue growth during pregnancy.

Commercial specifications

• Molecular weight approximately 511.5 g/mol; molecular formula C₂₀H₂₁CaN₇O₇
• Ph. Eur. and USP compendial standards
• Packaging: 1 kg and 5 kg units, scaling to 25 kg drums
• Cold-chain and controlled storage requirements observed throughout the supply chain