Calcium Folinate (leucovorin)

Calcium Folinate (leucovorin) (CAS 1492-18-8) is the calcium salt of folinic acid, a biologically active, reduced derivative of folic acid belonging to the Vitamin B9 family. With a molecular weight of approximately 511.5 g/mol and the molecular formula C₂₀H₂₁CaN₇O₇, it is widely recognised in both pharmaceutical and nutritional science for its direct metabolic availability, circumventing the conversion steps required by unmetabolised folic acid. In the pharmaceutical sector, Calcium Folinate is manufactured and supplied to Ph. Eur. and USP compendial standards, making it suitable for use in injectable preparations, oral solid dosage forms such as tablets, and lyophilised formulations. It is sourced by API manufacturers and finished-dose producers requiring a fully characterised, documented active substance with traceable batch records and full regulatory dossier support.

Two principal physical forms are available to formulators: a crystalline form, preferred for solid-state applications including tablet and capsule manufacture where flow and compressibility properties are critical, and an amorphous form, which may offer processing advantages in certain wet or solution-based systems. Selection between forms is typically driven by downstream processing requirements and the intended route of administration. Within the nutraceuticals and dietary supplement manufacturing sector, Calcium Folinate is used as a highly bioavailable B9 source. Manufacturers should note that this specific form is not listed in Annex II of Directive 2002/46/EC for use in food supplements in the EU; procurement teams are advised to confirm the applicable regulatory framework for their target market prior to specification. Authorised EU health claims under Regulation (EC) No 432/2012 for Vitamin B9 include contributions to normal amino acid synthesis, blood formation, homocysteine metabolism, normal immune system function, and normal maternal tissue growth during pregnancy.

In personal care and cosmetic applications, Calcium Folinate is of interest to formulators exploring B-vitamin actives for skin and scalp preparations, where its water solubility supports incorporation into aqueous systems and leave-on or rinse-off formats. SoleChem supplies Calcium Folinate in pharmaceutical-grade specifications aligned with Ph. Eur. and USP monographs. Packaging is offered in 1 kg and 5 kg units for development and small-batch production, scaling to 25 kg drums for commercial manufacturing volumes. Cold-chain and controlled storage requirements are observed throughout the supply chain to maintain material integrity.

Full technical documentation — including Certificate of Analysis, Safety Data Sheet, and where available, DMF references or regulatory support files — is available upon request. SoleChem's sourcing network covers qualified manufacturers with GMP certification, supporting customers across European and export markets requiring auditable, compliant raw material supply.