Vitamin B6 Pyridoxal 5'-Phosphate (P5P)

Vitamin B6 Pyridoxal 5'-Phosphate (P5P) (CAS 41468-25-1) is the biologically active coenzyme form of Vitamin B6, distinguished from precursor forms such as pyridoxine hydrochloride by its direct metabolic availability. Because it bypasses hepatic phosphorylation, P5P is the preferred active-form B6 source for formulators targeting high-bioavailability applications across the supplement, pharmaceutical, food, and personal care sectors. In nutraceutical and dietary supplement manufacturing, P5P is a well-established active ingredient for capsule, tablet, and softgel formats. It is listed in Annex II of Directive 2002/46/EC as a permitted vitamin source under the designation pyridoxal 5'-phosphate, confirming its regulatory status for use in food supplement products marketed within the European Union. Formulators should note it does not appear in the Annex II list under Regulation 1925/2006, and fortification claims should be assessed accordingly.

Authorised EU health claims under Regulation (EC) No 432/2012 for Vitamin B6 include contributions to normal protein and glycogen metabolism, red blood cell formation, the normal functioning of the immune system, homocysteine metabolism, and regulation of hormonal activity. These claims apply to Vitamin B6 as a nutrient category and are available to finished-product manufacturers where substantiated daily intake levels are met. In pharmaceutical applications, P5P is sourced to USP or Ph. Eur. compendial specifications where applicable, with full documentation including certificate of analysis (COA), heavy metals testing, microbial limits, and assay results. Pharmaceutical-grade supply supports both solid oral dosage forms and compounding applications where purity and batch traceability are critical procurement requirements.

For food and functional food applications, food-grade P5P powder is used in fortified products, meal replacements, and clinical nutrition formats. Its stability profile requires consideration during processing, particularly under conditions of elevated temperature or light exposure; suppliers typically provide stability data and recommended handling parameters alongside product documentation. In personal care and cosmetic formulations, P5P functions as an antioxidant and stabilising agent, with interest in scalp and hair care product development driven by Vitamin B6's recognised role in normal skin and hair follicle biology. Cosmetic-grade material is supplied with appropriate safety data and INCI-compliant identification.

SoleChem supplies Vitamin B6 Pyridoxal 5'-Phosphate in fine crystalline powder form, suitable for direct compression, encapsulation, and solution preparation. Standard packaging is available in 1 kg and 5 kg units for development and small production runs, with 25 kg fibre drums for bulk commercial orders. Documentation including COA, safety data sheet (SDS), and regulatory support files is available upon request for all grades.