Vitamin B3 Inositol Hexanicotinate

Vitamin B3 Inositol Hexanicotinate (CAS 6556-11-2) is the esterified form of niacin in which one molecule of inositol is bound to six nicotinic acid moieties. As a non-flushing niacin source, it is widely used across the nutraceutical, pharmaceutical, and personal care sectors as a tolerable alternative to free nicotinic acid, delivering equivalent vitamin B3 activity without the cutaneous vasodilation response associated with standard niacin supplementation. In nutraceutical and dietary supplement manufacturing, inositol hexanicotinate is listed in Annex II of Directive 2002/46/EC as an authorised vitamin B3 source for food supplements, making it a compliant ingredient for finished supplement formulations marketed within the EU. Supported authorised EU health claims under Regulation (EC) No 432/2012 recognise that niacin contributes to normal energy-yielding metabolism, normal functioning of the nervous system, normal psychological function, normal skin and mucous membranes, and the reduction of tiredness and fatigue — relevant claims for product label development at the B2B level.

Cardiovascular and metabolic health formulations represent a primary application area. Formulators in the supplement industry incorporate inositol hexanicotinate into softgels, tablets, and hard capsules targeting circulatory support and cholesterol management protocols, often at higher niacin-equivalent dosages where flush tolerance is a product differentiator. In the pharmaceutical sector, inositol hexanicotinate is handled to USP and Ph. Eur.-aligned specifications where applicable. Pharmaceutical-grade material supports active ingredient use in regulated drug products and combination formulations. Documentation packages including certificates of analysis, method of analysis references, and impurity profiles are available to support regulatory submissions.

For personal care and cosmetics applications, inositol hexanicotinate functions as a skin-conditioning agent and niacin precursor in topical formulations including serums, creams, and scalp treatments. It provides a milder niacin delivery vehicle suited to leave-on products where skin tolerability profiles are a formulation priority. SoleChem supplies inositol hexanicotinate in white to off-white crystalline powder form, with food-grade and pharma-grade options available depending on application requirements. Standard bulk packaging is offered in 25 kg fibre drums or cartons, with smaller quantities in 1–5 kg lots to support pilot-scale development and clinical batch manufacturing.

Full technical documentation, including specification sheets, safety data sheets, and regulatory support files, is available upon request. SoleChem operates as a European distributor with established logistics for prompt supply across EU member states. Contact our technical sales team to discuss grade suitability, lead times, and volume requirements for your specific formulation programme.