Fursultiamine

Fursultiamine (CAS 804-30-8), also widely referenced by its acronym TTFD (thiamine tetrahydrofurfuryl disulfide), is a lipophilic derivative of Vitamin B1 recognised for its enhanced membrane permeability compared to standard thiamine salts. This property makes it a technically differentiated active ingredient for formulators seeking improved bioavailability profiles in B1-containing products across pharmaceutical, nutraceutical, and personal care applications. In the pharmaceutical sector, fursultiamine is utilised as a Vitamin B1 source in prescription and OTC preparations where efficient thiamine delivery is a formulation priority. Its lipophilic character supports use in both oral solid dosage forms and topical systems. Manufacturers working to USP or Ph. Eur. compliance frameworks should confirm applicable monograph alignment with their quality team prior to procurement, as fursultiamine occupies a distinct position within the broader thiamine derivative category.

For nutraceutical and dietary supplement manufacturers, fursultiamine functions as a premium Vitamin B1 ingredient. Formulators should note that this specific form is not listed in Annex II of Directive 2002/46/EC for use in EU-marketed food supplements; regulatory suitability for target markets must therefore be verified prior to product development. Where Vitamin B1 is incorporated, authorised EU health claims under Regulation (EC) No 432/2012 apply: Vitamin B1 contributes to normal energy-yielding metabolism, normal functioning of the nervous system and heart, and normal psychological function. In personal care and cosmetic formulations, fursultiamine is considered for its role as a B-vitamin active in skin-conditioning and scalp-care contexts. Its solubility characteristics relative to standard thiamine salts may offer formulation advantages in certain emulsion and leave-on systems. Formulators should assess compatibility with their specific base systems and preservation strategies during development.

SoleChem supplies fursultiamine in powder form, with grades available to suit pharmaceutical, nutraceutical, and cosmetic manufacturing requirements. Material is sourced from audited production facilities operating under GMP conditions, and certificates of analysis including identity, purity, and microbiological data are supplied as standard documentation with each batch. Standard bulk packaging is offered in 25 kg fibre drums or cartons, providing a practical unit size for commercial-scale production. Smaller lots of 1–5 kg are available to support formulation development, pilot batches, and scale-up activities, ensuring continuity between laboratory and production quantities.

SoleChem maintains consistent European stock positions to support customers requiring reliable supply continuity. Technical documentation, regulatory support files, and sample requests can be directed to our product specialists to assist your qualification and procurement process.