Sulbutiamine

Sulbutiamine (CAS 3286-46-2) is a synthetic, lipid-soluble derivative of thiamine (vitamin B1), developed originally in Japan as a more bioavailable form of the parent vitamin.

Where is Sulbutiamine used?

• Pharmaceutical: active pharmaceutical ingredient (API) sourced to pharmaceutical-grade specifications
• Nutraceutical and specialist supplement manufacturing: incorporated into formulations targeting energy support and cognitive function
• Vitamin B1 activity is associated with authorised EU health claims under Regulation (EC) No 432/2012 for normal energy-yielding metabolism, nervous system, psychological and heart function.

Good to know: Not currently listed in Annex II of EU Directive 2002/46/EC governing food supplement source substances; regulatory due diligence is required before use in European finished supplement products. Health claims apply to the vitamin B1 activity of the compound.

Commercial specifications

• Molecular weight 702.89; empirical formula C₃₂H₄₆N₈O₆S₂
• Pharmaceutical grade typically assayed at ≥99.0% purity by HPLC
• Certificates of analysis cover identity (IR, HPLC), purity, heavy metals, residual solvents and microbiological status
• Packaging: 1 kg and 5 kg quantities; 25 kg fibre drums lined with double polyethylene bags