R-Alpha-Lipoic Acid

R-Alpha-Lipoic Acid (CAS 1200-22-2), commonly abbreviated as R-ALA, is the naturally occurring enantiomer of alpha-lipoic acid (thioctic acid) and the biologically active form recognised across nutraceutical, pharmaceutical, food, and personal care manufacturing. As a vitamin-like, sulfur-containing cofactor involved in mitochondrial energy metabolism, R-ALA is widely used as a functional ingredient where antioxidant activity and metabolic support are the primary formulation objectives. In the nutraceuticals and dietary supplement sector, R-ALA is supplied as a bulk active ingredient for encapsulated products, tablets, and stick-pack powders. Formulators specify the R-form specifically because it is the stereoisomer found endogenously, distinguishing it clearly from racemic alpha-lipoic acid. Finished-product manufacturers sourcing at scale typically require full batch documentation, including certificate of analysis (COA), safety data sheet (SDS), and technical data sheet (TDS), all of which SoleChem provides as standard.

Pharmaceutical and food-grade quality parameters for R-ALA align with established monograph criteria analogous to Ph. Eur. and USP specifications for thioctic acid, covering assay purity, chiral purity (optical rotation), heavy metals, residual solvents, and microbiological limits. Buyers operating under GMP conditions should confirm the applicable specification with our technical team prior to order placement. In food and nutrition applications, R-ALA functions as an antioxidant and stabiliser in functional food matrices and fortified beverages, where it contributes to oxidative stability in addition to its role as an active nutrient. Its use as a flavouring adjunct and mild acidulant is also documented in certain processed food formulations. Relevant EU and Codex categorisations should be verified by the receiving manufacturer according to the intended end-use and market of sale.

Personal care and cosmetic formulators incorporate R-ALA into topical preparations — serums, creams, and treatment products — for its antioxidant and skin-conditioning properties. It is compatible with standard emulsion and anhydrous systems, though its sensitivity to heat, light, and oxidation requires appropriate handling and formulation conditions to preserve activity. R-ALA is available from SoleChem in crystalline and fine-powder forms, with particle size and flow characteristics selectable to suit direct compression, wet granulation, or blending processes. Both standard and stabilised grades are available depending on application requirements.

Bulk packaging is offered in 25 kg fibre drums or cartons for large-volume orders, with 1–5 kg options available for development quantities, pilot batches, or initial qualification. All material is stored and dispatched under controlled conditions to maintain chiral integrity and antioxidant activity through the supply chain. Contact SoleChem to request samples, specifications, or delivery terms.